Centrifugal Partition Chromatography (CPC) Products
Discover the LiLiChro product line, built on advanced centrifugal partition chromatography (CPC) for scalable compound purification, from milligram-scale method development to kilogram-scale industrial processing. The product line includes miniLiLi, midiLiLi, maxiLiLi and prepLiLi CPC systems, all based on liquid-liquid chromatography principles without solid stationary phases.
This allows laboratories, pharma R&D teams, natural product producers and industrial purification teams to reduce sample loss, avoid column limitations and scale methods predictably across one CPC technology platform.
LiLiChro CPC Scale-Up Pathway
From Method Development to Industrial Purification
LiLiChro’s centrifugal partition chromatography products are designed as a connected CPC scale-up pathway. The same liquid-liquid chromatography principle can support early method development, laboratory purification, pilot-scale separation and industrial production, helping teams move from feasibility testing to scalable compound purification with less redevelopment.
Method development
miniLiLi
Sample amount
1–200 mg
Typical use
Method development, analytical applications, micro-preparations
Scale-up role
Develop and optimize the CPC method with low solvent consumption
Lab prep
midiLiLi
Sample amount
1–2 g
Typical use
Laboratory preparations, standards, replacing flash chromatography
Scale-up role
Bridge from method development to gram-scale purification
Pilot scale
maxiLiLi
Sample amount
100–150 g
Typical use
Pilot production, small pilot batches
Scale-up role
Scale validated methods to pilot-scale throughput
Industrial purification
prepLiLi
Sample amount
2–3 kg
Typical use
Continuous high-volume industrial chromatography
Scale-up role
Industrial purification and production-scale implementation
Combination
miniLiLi – "The smallest is the smartest"
CPC system for method development
For early feasibility testing, solvent-system screening and small-sample centrifugal partition chromatography workflows. Request the column loading test from our application notes collection.
It is the world’s smallest liquid-liquid chromatograph, but also the most flexible and powerful liquid-liquid chromatograph for its size, which can be used in a variety of experimental solutions. Its high efficiency ensures highly accurate results, even for industrial scale-up.
The miniLiLi works with spiral cells with an internal volume of 30 ml and a flow rate of 1-2 ml/min, so in many cases it is comparable to a conventional analytical HPLC. This is unique for the extensive laboratory-scale application of LLC.
Best practice offer:
The really "low hanging fruit" for labs!
As a new tool, it is the fastest and easiest solution to implement in terms of both capacity and knowledge, and works perfectly with our midiLiLi tool.
Basic technical informations
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General field of use: Labor
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Dimensions: 530 mm x 420 mm x 350 mm
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Cell capacity: 35 [mL]
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Sample injection volume: 10-50 [µL]
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Flow rate: 1-5 [ml/min]
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Max pressure: 80 bar
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Stationary phase retention >80%
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midiLiLi – "Queen of the labs"
Preparative Laboratory CPC purification system
For laboratory-scale purification when teams need higher loading capacity than analytical development, without moving directly to pilot scale.
This is LiLiCHRO and the world’s most efficient laboratory Centrifugal Partition Chromatography instrument, where scalability is now tangible. With an internal volume of 140 ml Z-cells and a flow rate of 5-15 ml/min, it is often comparable to a conventional lab-prep HPLC. It is the best tool for efficient technology transfer and the most accurate “antechamber” for industrial solutions.
Best practice offer:
use HPLC as CPC!
Simply replace your HPLC analytical column with a midiLiLi and you can use your standard analytical HPLC as a CPC.
Significant technical data
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Field of use: Laborprep
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Dimensions: 530 mm x 430 mm x 340 mm
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Cell capacity: 140 [mL]
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Sample injection volume: 2-10 [mL]
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Flow rate: 4-20 [ml/min]
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Max pressure: 100 bar
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Stationary phase retention >80%
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maxiLiLi – "World's first turn-out"
Preparative pilot-scale production CPC system
For scale-up studies, larger sample amounts and process-development work for changing production demand and seasonal projects.
The most efficient kg-scale CPC instrument in the world today, operating with 3 litre internal volume Z-cells and flow rates of 150-300 ml/min. The most powerful LiLiChro instrument in terms of size and performance, with excellent throughput, clarity and yield. It can be an essential tool for pilot-scale but industrial-scale projects.
Best practice offer:
The best value for money tool at industry level
Its application also provides the best basis for long-term business decisions.
Significant technical informations
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Field of use: small/pilot industrial
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Dimensions: 1080 mm x 730 mm x 950 mm
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Cell capacity: 3.5 L
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Sample injection volume: 50-500 mL
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Flow rate: 150-500 [ml/min]
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Max pressure: 80 bar
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Stationary phase retention >80%
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prepLiLi – "The industrial solution"
Industrial production scale CPC system
The world’s largest Centrifugal Partition Chromatography instrument for high-capacity purification and production-scale compound separation. The final instrument can be customized to fit existing infrastructure.
The volume expected from the device, building on the maxiLiLi’s output performance, carries a strong commitment from the device to high capacity production, with a 70 litre internal volume Z-cell and a flow rate of 2 l/min. It is a Taylor-made solution so that it can be put into operation under well-secured infrastructure and technician conditions.
Best practice offer:
The tool for large-scale industrial projects
Its application enables the achievement of sustainable business results, based on a solid technological advantage and market presence provided by the tool.
Significant technical data
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Field of use: industrial
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Dimensions: Custom design
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Cell capacity: 100 L
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Sample injection volume: 10-30 L
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Flow rate: 1-6 [L/min]
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Max pressure: 25 bar
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Stationary phase retention >80%
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The synergy of maxiLiLi & miniLiLi – “The Efficient Combination”
A smart solution from method development to production.
This unique package includes both the miniLiLi and the maxiLiLi instruments, enabling a smooth transition from R&D-scale method development to production-scale purification. The miniLiLi allows for fast and cost-effective method optimization, while the maxiLiLi ensures easy scalability without the need to redevelop the method.
In addition to the devices, LiLiChro provides essential services to support successful implementation:
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a screening study (SST) tailored to your target compound
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technical support during setup and process transfer
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The versatility of midiLiLi – “The Dynamic Solution”
A flexible bridge between research and industrial purification.
The midiLiLi offers the perfect balance between method development and production. Its scalable design enables continuous operation modes, including advanced setups such as True Moving Bed (TMB), making it highly effective for cost-efficient optimization and pilot-scale production. With midiLiLi, laboratories gain the ability to test and refine processes on a practical scale, while still ensuring a seamless transition to larger industrial systems without redeveloping the method.
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Frequently Asked Questions about
Centrifugal Partition Chromatography
What are centrifugal partition chromatography products used for?
Centrifugal partition chromatography products are used for preparative compound purification, molecule separation and scale-up workflows. They are especially useful when solid-phase chromatography causes sample loss, adsorption, high column costs or difficult scale-up.
Which LiLiChro CPC system is suitable for method development?
For early method development, miniLiLi is the typical starting point. It supports small-sample CPC testing, solvent-system screening and feasibility evaluation before moving to larger systems.
Is CPC scalable from lab development to industrial production?
Yes, in suitable applications CPC can replace or complement preparative HPLC and flash chromatography. It is most useful when columns are expensive, sample recovery is critical, or scale-up with solid-phase chromatography is difficult.
How does LiLiChro scale CPC purification from lab to industrial level?
LiLiChro supports CPC scale-up through miniLiLi, midiLiLi, maxiLiLi and prepLiLi. This pathway helps teams move from method development to lab, pilot, and industrial purification using the same liquid-liquid chromatography principle. Instead of continuous method development, scaling can be achieved by simple multiplication.
How do I know which CPC system fits my compound?
