1
Screening consultation
Discuss your compound, sample, purity goal and required scale.
Liquid-Liquid Chromatography for Scalable Compound Purification
LiLiCHRO
Discover the new generation of preparative chromatography that rethinks traditional extraction and purification workflows.
IS THIS RELEVANT TO YOUR WORK?
Preparative purification for complex compounds and scalable processes
LiLiChro helps purification teams evaluate and implement liquid-liquid chromatography for difficult separations, scale-up, and cost-sensitive purification workflows.
Industries
Organisations
START HERE
See when CPC is worth considering
- Reduce dependency on packed columns
- Improve recovery for adsorption-prone compounds
- Evaluate whether the method can scale
120-sec overview
Understand where liquid-liquid chromatography fits in your purification workflow
COMMON PURIFICATION BOTTLENECKS
What is holding your purification back?
Many preparative workflows become limited by recovery, loading, scale-up or operating cost. Here are four situations where liquid-liquid chromatography may be worth evaluating.
Losing valuable product?
Strong adsorption, difficult elution and poor recovery can make valuable compounds disappear during purification.
LILICHRO SOLUTION
Separate without a solid stationary phase and reduce adsorption-related losses.
Can't increase the load without losing purity?
As packed columns are pushed harder, peak shape, resolution and recovery often begin to deteriorate.
LILICHRO SOLUTION
Explore higher preparative loading with liquid-liquid partitioning instead of silica adsorption capacity.
Does scale-up mean developing the method again?
Larger columns change geometry, pressure, flow and loading behaviour, often forcing additional optimisation.
LILICHRO SOLUTION
Develop around the same biphasic solvent-system logic from screening toward production scale.
Are columns and solvents becoming a recurring cost?
Silica, cartridges, replacement, regeneration and solvent handling can make purification progressively more expensive.
LILICHRO SOLUTION
Remove the consumable solid stationary phase and build around recoverable liquid phases where suitable.
Your purification challenge is unique?
Tell us what you are trying to separate.
COMMON CONCERNS
Your questions. Our answers.
A new purification technology can raise questions. Here are the most common concerns we hear – and how we address them.
Concern
We already have an HPLC or flash process.
Why consider another technology?
We don’t know this technology.
Our team has no experience with CPC.
It sounds expensive and risky.
New technology, new costs, uncertain outcome.
How do we know it will work for our compound?
Our separation is unique and challenging.
The LiLiChro approach
You don’t need to replace what already works.
We help you identify where CPC can add value – as an alternative or complementary solution.
You don’t need to become a CPC expert first.
We support solvent-system selection, method development, instrument training and process transfer.
Test the separation before committing to an instrument.
Our screening and feasibility studies de-risk the process and provide real data for your decision.
Start with your compound, not with the instrument.
We evaluate your separation challenge first and can test the method with your actual sample.
Companies who trust us:
A CLEAR WAY FORWARD
From your question to a proven process.
A structured and low-risk approach to explore what CPC can do for you.
- Get in touch – we usually reply within 1 business day.
2
Feasibility study
We run small-scale tests to evaluate separation performance and confirm feasibility.
3
Instrument training
Hands-on training for your team to ensure confident and successful operation.
4
Installation & scale-up
We support installation and scale-up to help you deliver results in your lab or production environment.
PROOF IN NUMBERS
Performance you can measure
Five technical proof points that show how LiLiChro CPC systems support scalable preparative purification.
100%
SCALE-UP
Same method from lab to production
95+%
Purity
Meet demanding purification targets
90+%
Yield
Recover more valuable product
0
Silica columns
No packed solid stationary phase
2–15 bar
Low pressure
Typical low-pressure operation across the LiLiChro platform
One method. Four scales.
From milligrams to kilograms
Performance depends on compound, solvent system and operating conditions
Need the technical details behind these numbers?
Talk to our team about application notes, case studies and method development data.
COST EFFICIENCY
See what your columns really cost.
Preparative columns are a major cost driver in purification. Calculate your annual column cost and see the potential savings with a column-free CPC approach.
Eliminate column costs
No silica, no column replacement, no disposal.
Lower operating costs
Less solvent, less waste, fewer consumables.
LiLiChro cost calculator
What do your columns cost each year?
Enter three values to estimate your annual preparative column cost.
€
runs
runs
Annual column cost = columns required per year × average column cost. Partial columns are rounded up.
Let’s talk
Don't miss the opportunity to simplify your purification.
Whether you have a specific project or just want to explore the possibilities, our experts are here to help.
THE COST OF WAITING
Every month with the same bottlenecks costs you time and money.
Columns, high solvent use and non-linear scale-up keep increasing your costs and delaying your project.
THE VALUE OF KNOWING
A short conversation can open new possibilities.
Get a clear, expert perspective on whether CPC is a good fit for your separation challenge – and what it could unlock for your process.
Get in touch
Start the conversation
Tell us about your project and we will get back to you shortly.