Laszlo Frici Nemeth

founder, chief engineer of Lilichro, inventor and patent holder of our cutting edge CPC device

Stop guessing if CPC is the right purification technology for your process.

Find out in 5 minutes. Download the engineering checklist designed to reveal if Liquid-Liquid Chromatography can eliminate your silica costs and boost your yield.

After 31 years in separation sciences, I see it constantly: companies miss out on massive OPEX savings because they don’t have clear data on CPC. I developed this exact checklist to tell you quickly and honestly whether CPC is worth exploring for your specific case.”

– László Frici Németh

What is CPC?

Liquid-liquid chromatography (LLC) is a powerful, high-recovery separation technique where both the stationary and mobile phases are immiscible liquids.

Zero silica costs

No solid stationary phase to replace.

Maximum yield

Zero irreversible adsorption. No sample loss.

Lower OPEX

Uses standard, industrial-grade solvents.

Linear scale-up

100% predictable transition from lab to production.

Worldwide support

Deployed and fully serviced across four continents.

Learn more about Centrifugal Partition Chromatography at our dedicated Technology site:

Technical & operational comparison

Solid phase vs. liquid-liquid

Comparison table of HPLC, Flash Chromatography, and CPC by purification metric.
Metric	HPLC	Flash Chromatography	Centrifugal Partition Chromatography
Separation principle	Solid-liquid Adsorption or partitioning on a packed solid column.	Solid-liquid Adsorption on silica or another disposable packed medium.	Liquid-liquid Partitioning between two immiscible liquid phases.
Product recovery	Possible losses from irreversible adsorption on solid media.	Possible losses due to adsorption, broad bands, and cartridge retention.	Very high; the liquid stationary phase can be flushed out after the run.
Consumables cost	High; preparative columns and resins are recurring expenses.	High; cartridges and silica are consumed continuously.	Low; no silica, no resin bed, no disposable column.
Waste profile	Solvent waste plus spent columns or resin replacement.	High solvent and silica waste.	No solid stationary-phase waste; compatible with solvent recovery and recycling. [GREEN]
Scale-up predictability	Often empirical and column-dependent.	Limited; mainly suited for lab and early preparative work.	More linear; based on phase ratios, rotor volume, flow rate, and loading.
Best use case	Final polishing of APIs, analytical methods, and high-resolution separations.	Fast purification of synthetic intermediates in R&D.	Crude natural products, cannabinoids, peptides, complex extracts, and high-recovery purification.